Genetic aspects of injury as one of the criteria for sports selection
Abstract and keywords
Abstract (English):
The purpose of the study is an analytical review of the literature data on the assessment of the genetic nature of injuries in diving as one of the criteria for sports selection. Research methods: analysis of literature in the PubMed, Cochrane, Medline, and Google Scholar databases. Research results and conclusions. An overview is presented of the genes that determine susceptibility to musculoskeletal injuries in divers. It is shown that the use of genetic analysis in sports practice to assess the most promising athletes in diving can be of a recommendatory and informational nature. Further research is needed to deepen the understanding of the genetic basis of injuries and to develop effective approaches to sports selection and injury prevention. For this, it is important to consider the characteristics of genetics, epigenetics, and the environment (training, rest, nutrition, psycho-emotional state, etc.). This approach will help improve athletic performance and reduce the risk of musculoskeletal sports injuries.

Keywords:
diving, sports genetics, sports injuries, sports selection
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References

1. Moran C. N., Pitsiladis Y. P. (2017), “Tour de France Champions born or made: Where do we take the genetics of performance?”, J. Sports Sci, No. 35, pp. 1411–1419, DOIhttps://doi.org/10.1080/02640414.2016.1215494.

2. Balberova O. V. [et al.] (2021), “Model characteristics of competition performance in terms of atletes, functional fitness”, Sci. Educ. Today, V. 11, No. 3, pp. 161–176, DOIhttps://doi.org/10.15293/2658-6762.2103.09.

3. Collins M. (2010), “Genetic risk factors for soft-tissue injuries 101: a practical summary to help clinicians understand the role of genetics and ‘personalised medicine’”, British journal of sports medicine, V. 44, No. 13, pp. 915–917, DOIhttps://doi.org/10.1136/bjsm.2009.058040.

4. Currie B. M., Hetherington M., Waddington M. G. [et al.] (2024), “Injury epidemiology in male and female competitive diving athletes: A four-year observational study”, Journal of Science and Medicine in Sport, Vol. 27, Issue 12, pp. 849–855, URL: https://doi.org/10.1016/j.jsams.2024.08.204.

5. Ma R., Brimmo O.A., Li X., Colbert L. (2017), “Current Concepts in Rehabilitation for Traumatic Anterior Shoulder Instability”, Curr Rev Musculoskelet Med., Vol. 10 (4), pp. 499–506, DOIhttps://doi.org/10.1007/s12178-017-9449-9.

6. Jones N. S. (2017), “Competitive Diving Principles and Injuries”, Curr Sports Med Rep., Vol. 16 (5), pp. 351–356, DOIhttps://doi.org/10.1249/JSR.0000000000000401.

7. Mountjoy M. (2009), “Injuries and medical issues in synchronized Olympic sports”, Curr Sports Med Rep., Vol. 8 (5), pp. 255–261, DOIhttps://doi.org/10.1249/JSR.0b013e3181b84a09.

8. Lian O. B. [et al.] (2005), “Prevalence of jumper's knee among elite athletes from different sports: a cross-sectional study”, The American Journal of Sports Medicine, No. 33(4), pp. 561–567, DOIhttps://doi.org/10.1177/0363546504270454.

9. Hoffmann A., Gross G. (2007), “Tendon and ligament engineering in the adult organism: mesenchymal stem cells and gene-therapeutic approaches”, International orthopaedics, V. 31, No. 6, pp. 791–797, DOI:https://doi.org/10.1007/s00264-007-0395-9.

10. Collins M., Raleigh S. M. (2009), “Genetic risk factors for musculoskeletal soft tissue injuries”, Med Sport Sci, No. 54, pp. 136–49, DOIhttps://doi.org/10.1159/000235701.

11. Maffulli N. [et al.] (2013), “The genetics of sports injuries and athletic performance”, Muscles Ligaments Tendons J., Vol. 3, No. 3, pp. 173–189, DOIhttps://doi.org/10.11138/mltj/2013.3.3.179.

12. Pfeifer C. E., Beattie P. F., Sacko R. S., Hand A. (2018), “Risk factors associated with non-contact anterior cruciate ligament injury: a systematic review”, Int J Sports Phys Ther., Vol. 13 (4), pp. 575–587.

13. Posthumus M. [et al.] (2009), “Genetic risk factors for anterior cruciate ligament ruptures: COL1A1 gene variant”, Br J Sports Med, V. 43, No. 5, pp. 352–356, DOIhttps://doi.org/10.1136/bjsm.2008.056150.

14. Mann V. [et al.] (2001), “A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality”, J Clin Invest, Vol. 107, No. 7, pp. 899–907, DOIhttps://doi.org/10.1172/JCI10347.

15. Khoschnau S. [et al.] (2008), “Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations”, Am J Sports Med., Vol. 36, No. 12, pp. 2432–2436, DOIhttps://doi.org/10.1177/0363546508320805.

16. Ficek K. [et al.] (2013), “Gene variants within the COL1A1 gene are associated with reduced anterior cruciate ligament injury in professional soccer players”, Journal of science and medicine in sport, Vol. 16, No. 5, pp. 396–400, DOIhttps://doi.org/10.1016/j.jsams.2012.10.004.

17. Stepien-Slodkowska M. [et al.] (2013), “The +1245g/t polymorphisms in the collagen type I alpha 1 (col1a1) gene in polish skiers with anterior cruciate ligament injury”, Biology of sport, V. 30, No. 1, pp. 57–60, DOIhttps://doi.org/10.5604/20831862.1029823.

18. Erduran M. [et al.] (2014), “Is Sp1 binding site polymorphism within COL1A1 gene associated with tennis elbow?”, Gene, Vol. 537, No. 2, pp. 308–311, DOIhttps://doi.org/10.1016/j.gene.2013.12.014.

19. Stepien-Slodkowska M., Ficek K., Zietek P. [et al.] (2017), “Is the Combination of COL1A1 Gene Polymorphisms a Marker of Injury Risk?”, J Sport Rehabil., Vol. 26 (3), pp. 234–238, DOIhttps://doi.org/10.1123/jsr.2015-0151.

20. Lim S. T., Kim C. S., Kim W. N., Min S. K. (2015), “The COL5A1 genotype is associated with range of motion”, Physical Activity and Nutrition, Vol. 19 (2), pp. 49–53, DOIhttps://doi.org/10.5717/jenb.2015.15052701.

21. Mokone G. G. [et al.] (2006), “The COL5A1 gene and Achilles tendon pathology”, Scand J Med Sci Sports, V. 16, No. 1, pp. 19–26, DOIhttps://doi.org/10.1111/j.1600-0838.2005.00439.x.

22. Raleigh S. M., van der Merwe L., Ribbans W. J. [et al.] (2009), “Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene”, Br J Sports Med., Vol. 43 (7), pp. 514–520, DOIhttps://doi.org/10.1136/bjsm.2008.053892.

23. Lippi G., Longo U. G., Maffulli N. (2010), “Genetics and sports: the present and the future”, Br Med Bull, V. 93, No. 1, pp. 27–47, DOIhttps://doi.org/10.1093/bmb/ldp007.

24. Shi X. [et al.] (2023), “Targeting Hub Genes Involved in Muscle Injury Induced by Jumping Load Based on Transcriptomics”, DNA Cell Biol, V. 42, No. 8, pp. 498–506, DOI:https://doi.org/10.1089/dna.2022.0285.

25. Herrera D. G., Robertson H. A. (1996), “Activation of c-fos in the brain”, Progress in Neurobiology, V. 50, No. 2-3, pp. 83–107, DOI:https://doi.org/10.1016/S0301-0082(96)00021-4.

26. Jones M. W. [et al.] (2001), “A requirement for the immediate early gene Zif268/Egr1 in the expression of late LTP and spatial long-term memory”, Nature Neuroscience, V. 4, No. 3, pp. 289–296, DOIhttps://doi.org/10.1038/85138.

27. Kawauchi J., Zhang C., Nobori K. [et al.] (2002), “Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription”, J Biol Chem., Vol. 277 (41), pp. 39025–39034, DOIhttps://doi.org/10.1074/jbc.M202974200.

28. Liu S., Li Z., Lan S. [et al.]. “ATF3 in Inflammation, Apoptosis, Ferroptosis, and Pathogen Infection”, Encyclopedia, URL: https://encyclopedia.pub/entry/55192 (accessed on 24 October 2025).

29. Massidda M. [et al.] (2015), “Vitamin D receptor gene polymorphisms and musculoskeletal injuries in professional football players”, Exp Ther Med, V. 9, No. 5, pp. 1974–1978, DOIhttps://doi.org/10.3892/etm.2015.2364.

30. Yang N. [et al.] (2003), “ACTN3 genotype is associated with human elite athletic performance", American Journal of Human Genetics, V. 73, No. 3, pp. 627–631, DOIhttps://doi.org/10.1086/377590.

31. Riedl I., Osler M. E., Benziane B. [et al.] (2015), “Association of the ACTN3 R577X polymorphism with glucose tolerance and gene expression of sarcomeric proteins in human skeletal muscle”, Physiol Rep., Vol. 3 (3), pp. 12314, DOIhttps://doi.org/10.14814/phy2.12314.

32. Longo U. G. [et al.] (2015), “Unravelling the genetic susceptibility to develop ligament and tendon injuries”, Curr Stem Cell Res Ther, V. 10, No. 1, pp. 56–63, DOIhttps://doi.org/10.2174/1574888x09666140710112535.

33. Van Heyningen V., Yeyati P. L. (2004), “Mechanisms of non-Mendelian inheritance in genetic disease”, Hum Mol Genet, V. 13, No. 2, pp. R225.

34. Pickering C. [et al.] (2019), “Can Genetic Testing Identify Talent for Sport?”, Genes, V. 10, No. 12, p. 972.

35. Vlahovich N. [et al.] (2017), “Ethics of genetic testing and research in sport: A position statement from the Australian Institute of Sport”, Br. J. Sports Med, V. 51, No. 1, pp. 5–11, DOIhttps://doi.org/10.1136/bjsports-2016-096661.

36. Williams A. G., Wackerhage H., Day S. H. (2016), “Genetic testing for sports performance, responses to training and injury risk: Practical and ethical considerations”, Med. Sport Sci., V. 61, pp. 105–119, DOIhttps://doi.org/10.1159/000445244.

37. Pickering C., Kiely J. (2017), “Can the ability to adapt to exercise be considered a talent-And if so, can we test for it?”, Sports Med. Open, V. 3, No. 1, p. 43, DOIhttps://doi.org/10.1186/s40798-017-0110-3.

38. Pickering C. [et al.] (2018), “The magnitude of Yo-Yo test improvements following an aerobic training intervention are associated with total genotype score”, PLoS One, V. 13, No. 11, p. e0207597, DOIhttps://doi.org/10.1371/journal.pone.0207597.

39. Jones N. [et al.] (2016), “A genetic-based algorithm for personalized resistance training”, Biol. Sport, V. 33, No. 2, p. 117–126, DOI:https://doi.org/10.5604/20831862.1198210.

40. Heffernan S. M. [et al.] (2015), “Genomics in rugby union: A review and future prospects”, Eur. J. Sport Sci, V. 15, No. 6, pp. 460–468, DOIhttps://doi.org/10.1080/17461391.2015.1023222.

41. Cecile A., Janssens J. W., Joyner M. J. (2019), “Risk Scores That Predict Common Diseases Using Millions of Single Nucleotide Polymorphisms: Is More, Better?”, Clin Chem, V. 65, No. 5, pp. 609–611, DOIhttps://doi.org/10.1373/clinchem.2018.296103.

42. Ehlert T., Simon P., Moser D. A. (2013), “Epigenetics in sports”, Sports Med., V. 43, No. 2, pp. 93–110, DOIhttps://doi.org/10.1007/s40279-012-0012-y.

43. Luo W., Nie Q., Zhang, X. (2013), “MicroRNAs involved in skeletal muscle differentiation”, J. Genet. Genomics, V. 40, No. 3, pp. 107–116, DOIhttps://doi.org/10.1016/j.jgg.2013.02.002.

44. Voisin S. [et al.] (2015), “Exercise training and DNA methylation in humans”, Acta Physiol., V. 213, No. 1, pp. 39–59, DOIhttps://doi.org/10.1111/apha.12414.

45. Richards E. J. (2006), “Inherited epigenetic variation-Revisiting soft inheritance”, Nat. Rev. Genet, No. 7, p. 395–401, DOIhttps://doi.org/10.1038/nrg1834.

46. Lokk K. [et al.] (2014), “DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns”, Genome Biol., V. 15, No. 4, p. 1–14, DOIhttps://doi.org/10.1186/gb-2014-15-4-r54.

47. Hall E. C. R. [et al.] (2020), “The prospective study of epigenetic regulatory profiles in sport and exercise monitored through chromosome conformation signatures”, Genes, V. 11, No. 8, p. 1–19, DOIhttps://doi.org/10.3390/genes11080905.

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